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Disputationer NOVEMBER 2010 Nastaran Monsef 2
1 mg/kg. (a). Arsenic. 1 mg/kg. 2 mg/kg.
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2020-09-24 · Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regulation of apoptosis and autophagy; promotion of the intracellular production of reactive oxygen species, causing oxidative damage; and inhibition of tumor stem cells. However, glioma HIGHLIGHTS OF PRESCRIBING INFORMATION TRISENOX® (arsenic trioxide) injection These highlights do not include all the information needed to use TRISENOX safely and effectively. See full prescribing information for TRISENOX.
Queen Emma 1850-1913 [WorldCat Identities]
Int. J. Hematol. 97 717–725. 10.1007/s12185-013-1354-4 [Google Scholar] Tsuzuki S., Taguchi O., Seto M. (2011).
probukol — Engelska översättning - TechDico
Oct 5, 2015 Arsenic(III) oxide react with sodium hydroxide to produce sodium metaarsenite and water. Chemical reaction. Balancing chemical equations. Arsenic Element Facts. Data Zone | Discovery | Facts | Appearance & Characteristics | Uses | Abundance & Isotopes | References.
Substantial data show that arsenic trioxide produces remissions in patients with APL at least in part through a mechanism that results in the degradation of the aberrant PML-retinoic acid receptor alpha fusion protein. The mechanism of action of arsenic trioxide is not well understood. There is speculation that it causes death of leukemia cells via morphological changes and DNA fragmentation. Arsenic Trioxide also damages or degrades the fusion protein promyelocytic leukemia (PML) - retinoic acid receptor (RAR) alpha. 2002-07-01 · These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses.
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T1 - Arsenic trioxide. AU - Litzow, Mark R. PY - 2008/7/1. Y1 - 2008/7/1.
Biol., (21):7172-7182 MED: 11585900
To study the anti-tumor effect of arsenic trioxide on the HepG2 human hepatocellular carcinoma cell line, and to explore its mechanism of action. The MTT assay was used to determine the inhibitory effect of As2O3 on HepG2 cells at various As2O3 concentrations.
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Queen Emma 1850-1913 [WorldCat Identities]
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsed patients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression.
Annals of internal medicine
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probucol — Svenska översättning - TechDico
The interaction of As2O3 with sulphydryl groups on these targets seems to be a common mechanism of action. This is consistent with the 2008-09-09 · The mechanism of action of arsenic trioxide is mainly related to the induction of apoptosis (programmed cell death) in cancer cells. In particular it involves effects on the activities of JNK kinases, NF-kB transcription factor, glutathione, caspases, as well as pro- and anti-apoptotic proteins. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses. Substantial data show that arsenic trioxide produces remissions in patients with APL at least in part through a mechanism that results in the degradation of the aberrant PML-retinoic acid receptor alpha fusion protein. The mechanism of action of arsenic trioxide is not well understood.